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This creates a catastrophic bottleneck in the liver
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10.1016/j.bbrc.2004.09.220 Biochem Biophys Res Commun
Symptoms often begin after pregnancy, trauma, major surgery, or a viral illness (1, 2, 3)
This directly ties creatine supplementation to sparing methyl groups for homocysteine remethylation.[ref][ref][ref] For people with MTHFR variants, this connection may matter even more because the methylation cycle can already be less efficient
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