demonstrated that oral administration of the DPP inhibitor sitagliptin (50 mg/kg) can enhance cognitive function and protects neurons against oxidative stress in high fat-fed mice ( in vitro study reported that exendin-4 increases the number of neurites, promotes neuronal outgrowth, and considerably increases neurite length (Luciani et al., 2010)
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We are very encouraged by the results of the PIONEER 1 trial, which confirm the unprecedented oral efficacy of semaglutide that was reported in the Phase II clinical trial in type 2 diabetes, said Mads Krogsgaard Thomsen, Novo Nordisk executive vice president and chief science officer, in a statement
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