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In concordance with this regulatory scheme, ablating IGF-IR genes in cultured chondrocytes inhibits the ability of high [Ca 2+ ] e (by 50%) to enhance terminal differentiation and matrix mineralization, supporting a role for IGF-I/IGF-IR signaling in mediating CaSR-induced chondrocyte differentiation (Figure 1)

Reserpine is the active ingredient of a herbal tranquillizer from Rauwolfia serpentina discovered by ancient Indian physicians

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B-12 injections are typically administered weekly, bi-weekly, or monthly depending on practitioner protocols and patient symptoms

doi: 10.23937/2378-3656/1410281 97 DesaiAPetrovJHashashJGPatelHBrahmbhattBKochharGSet al