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reported that a single knockout of Hsf2 resulted in reduced testicular volume and mild spermatogenic abnormalities, whereas mice with a double knockout of Hsf1 and Hsf2 were completely infertile (Wang et al., 2004)

Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, et al

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If results continue to be strong, they could be available in 24 years