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DPP-4 inhibitors, such as sitagliptin, alogliptin, linagliptin and saxagliptin, were synthesized to prolong the half-life of GLP-1 (102)

In terms of translational medicine, this review evaluates the therapeutic potential of targeting polarization strategies, covering small molecule drugs, metabolic modulators, immunotherapy, as well as reprogramming techniques based on exosomes or gene editing, and discusses major challenges in clinical translation, such as microenvironment dependency, limitations in delivery systems, and the lack of biomarkers

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Fiber: Found in fruits, vegetables, beans, lentils, chia seeds, and whole grains, fiber keeps digestion regular and helps you feel fuller longer

Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance