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Ethics, reproducibility and methodological pitfalls Frequent pitfalls in cognitive peptide research No vehicle control in some old Russian studies: mandatory in any modern publication Non-randomisation : assigning animals to groups by order of arrival introduces systematic bias (weight, oestral cycle, cage stress) Non-blinded experimenter : behavioural tests are highly sensitive to expectations

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GSH is found in all mammalian tissues as the most abundant non-protein thiol that defends against oxidative stress and possess a distinctive stability provided by a -carboxyl bond within the molecule (Figure 1A)

In the case of most healthy adults, there is no need to worry because the oral glutathione used daily in the long term should not have any harm provided it is not exceeded

TREATMENT LENGTH 30 60 minutes per relaxing session