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proposed that exenatide upregulates uncoupling protein-3 (UCP-3) and nuclear respiratory factor-1 (Nrf-1) in cardiomyocytes subjected to ischemia/reperfusion (I/R) via the cAMP/PKA pathway, thereby facilitating mitochondrial homeostasis [93]
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Given that Metformin is contraindicated in cases of acute kidney injury or severe renal impairment, dosage modifications may be required depending on kidney function
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2017Q13), and China Postdoctoral Science Foundation (No
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