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Under physiological conditions, it supports synaptic plasticity [346], whereas under pathological states, such as during astrocytic necroptosis, proBDNF may exert neurotoxic effects and promote apoptotic signaling [349]
Boroughs LK, DeBerardinis RJ
Given as a subcutaneous injection, near the area of interest for localized effects or in the abdomen for systemic goals (gut, general recovery)
Endocrinology (2016) 157:107181
This aligns with bacteriostatic water's shelf life after opening
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