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It has a lower affinity for the ghrelin receptor and can produce more negative side effects

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This is usually linked to how the body responds to changes in appetite, energy intake, and daily routine

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Khnen P, Krude H, Biebermann H

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If you're taking an antidepressant known for GI effects, your provider might recommend starting semaglutide at a lower dose or adjusting your antidepressant timing

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Muscle matters: the effects of medically induced weight loss on skeletal muscle

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