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Many patients remain at lower doses for longer periods if they are experiencing adequate appetite control and weight-loss progress
In the presence of 4-hydroxytamoxifen (4OHT), Cre is trafficked to the nucleus where it removes the loxP-flanked STOP codon to allow for transcription of tdTomato or other genes
It reminds you that problems are a normal part of the process and that being persistent is often what leads to success
Rare but serious side effects include pancreatitis, gallbladder disease, and the theoretical risk of thyroid C-cell tumors seen in animal studies (not confirmed in humans at therapeutic doses)
PKC activation disrupts normal metabolism, leading to ATPase phosphorylation and metabolic disorders, including changes in VEGF and vasoconstriction, which affect pain perception
