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Its approved for premenopausal women (though its sometimes prescribed off-label for women past menopause)

it is precisely this property that critics flag as an unquantified concern, for example in the context of occult neoplasia or proliferative diseases

Oxidative stress may contribute to processes involved in cardiovascular disease, including endothelial dysfunction, LDL oxidation, inflammation, mitochondrial injury, and plaque formation

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But as a neurophysiologist, the cancer risk isnt even what concerns me most