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5.1 Growth-promoting mode: lipid anabolism and metabolic adaptation In metabolically permissive environmentscharacterized by sufficient nutrient availability and limited oxidative stressACSL4 primarily supports tumor progression

Taken together, these data demonstrate that cancer cells capable of enduring 5FU treatment have significant, sustained mitochondrial adaptations, driving enhanced mitochondrial biogenesis and fusion in the absence of evident mitochondrial dysfunction

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