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The Case Against Routine Use The American Academy of Dermatology (AAD) 2022 guidelines on isotretinoin use state: "Patients should be counseled to avoid supplements with teratogenic potential (vitamin A, retinoids) and to disclose all supplement use, as interactions with antioxidant supplements have not been adequately studied in the context of isotretinoin therapy." [11] The guidelines do not specifically name ALA, but the intent is clear: supplement co-administration during isotretinoin requires individualized clinical judgment

With ageing, glutathione levels decrease, and to combat this, many people rely on glutathione injections