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By contrast, the initial studies on GLP-1RA related peptide polyagonists in animal models of NAFLD have to date provided more encouraging results as regards their effect on hepatic fibrosis (Table 2)
Both semaglutide (brand names Ozempic, Wegovy) and tirzepatide (Mounjaro) are glucagon-like peptide-1 (GLP-1) receptor agonists that work by mimicking a hormone to reduce appetite, however tirzepatide uniquely also activates the glucose-dependent insulinotropic polypeptide (GIP) receptor unlike semaglutide which only activates the GLP-1 receptor
Its a triple-agonist peptide , meaning it activates three major systems simultaneously: GLP-1 reduces hunger and slows digestion GIP enhances metabolic efficiency Glucagon increases energy expenditure This combination leads to: Eating less without constant willpower Better blood sugar regulation Increased calorie burn at rest The clinical data is already strong Even in earlier trials, the results were hard to ignore: Up to ~24% total body weight loss in Phase 2 studies Around 17% weight loss in type 2 diabetes patients , alongside improved glucose control Up to 82% reduction in liver fat in individuals with fatty liver disease This isnt just weight lossits full metabolic change
Similarly, Lin et al
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