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While they share similarities in purpose, their mechanisms of action and dosing differ
According to NICE guidance (NG145), treatment with levothyroxine is typically recommended when TSH is 10 mIU/L on two separate occasions, with individualised decisions for lower TSH levels based on symptoms and risk factors
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The 64mg pen doubles those figures, which is why it tends to appear on multi-arm or extended-duration protocols
Many insurers require prior authorization and documentation of a qualifying BMI or weight-related condition
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