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J Diabetes Res (2020) 2020:8843310

So, how long does it take for semaglutide to work

Watch for mild GI side effects (nausea, constipation) during extended studies

In general, they have a small introductory dose that serves as a kind of loading phase to get your body used to the drug, a larger dose for ongoing treatment, and potentially several higher doses for those who need more serious control