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2009 Nov;37(11):225561
Anton Simeonov Ph.D
In addition, deletion of the GSH1 geneencoding glutamylcysteine synthetase (GCS), the enzyme catalysing the first step in glutathione synthesiswas shown to suppress an Ero1 conditional mutant, again indicating that GSH provides an additional load on Ero1 activity (Frand & Kaiser, 1998)
1 The external sources of reactive oxygen species (ROS) are cigarette smoke, environmental pollutants, radiation, certain drugs, pesticides, industrial solvents, and ozone
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