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de Boer IH, et al
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According to FDA prescribing information, these adverse effects were dose-dependent and contributed to treatment discontinuation in clinical trials
At weight loss doses, semaglutide produces HbA1c reductions of 1.0-1.8 percentage points, while liraglutide produces 0.5-1.0 percentage point reduction
Early pregnancy losses and increased incidences of minor visceral (kidney, liver) and skeletal (sternebra) fetal abnormalities were observed at 0.0025 mg/kg/day, at clinically relevant exposures
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