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-endorphin, the POMC-derived opioid peptide, has the capacity to upregulate melanogenesis and melanin distribution by promoting maturation of melanocytes and arborisation of their dendritic processes, thus increasing the efficacy of the transfer and distribution of melanosomes to neighbouring keratinocytes [23, 29]
CaNa 2 EDTA, however, cannot penetrate cellular membranes due to its ionic form and therefore its use is generally restricted to removing metal ions from their complexes within the extracellular compartments of the body
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