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In mitochondria, LA is a vital cofactor for several enzymes (the oxoglutarate dehydrogenase complex [OGDC], pyruvate dehydrogenase complex [PDHC], branched-chain -ketoacid dehydrogenase complex [BCKDC]) that contribute to aerobic metabolism and nucleic acid synthesis [32, 33]
Differences in pharmacokinetic profiles among GLP-1 RAs may also contribute to variability in GI tolerability, with longer-acting agents generally associated with more persistent, though often less intense, symptoms compared with short-acting formulations
Biliary Epithelial Cells Similar to hepatocyte it was proposed that biliary epithelial cells (i.e., cholangiocytes) can change their fate and transit to invasive fibroblasts by EMT
They say Novo Nordisk's Wegovy and Eli Lilly's Zepbound aren't covered by their insurance
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