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Insulin dose reduction of 20 to 50% at triple agonist initiation is consistent with the approach used in tirzepatide trials: the SURPASS-5 trial (N=475) reduced insulin glargine by 20% at tirzepatide initiation, which reduced hypoglycemia without sacrificing glycemic control
Personalized medicine: Advances in pharmacogenomics may allow for more targeted use of GLP-1s, optimizing efficacy and minimizing side effects based on individual genetic profiles
(2018) ( Epub 2016 Oct 18 )
Lean muscle gains of 3 to 8 pounds occur in the same timeframe
doi: 10.1172/JCI69600 16 van GeldermalsenMWangQNagarajahRMarshallADThoengAGaoDet al
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