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Many patients will not experience the full therapeutic effects until reaching higher maintenance doses, which typically occurs after 8 to 12 weeks of gradual dose escalation

As cheaper versions become widely available, adherence and continuity of care could become major concerns

Im a big fan of Nooms philosophy that small steps can lead to big change, said Rebel Wilson

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The second concerns endpoints: a program built around biomarker movement needs a clear, pre-specified theory of how that biomarker connects to clinical benefit, and a plan for what a divergence would mean