It gets cheaper when you buy in larger volumes at a time
In the decades since, researchers have repeatedly returned to it as an open question in neurochemistry, with one influential review aptly describing it as a "still unresolved riddle" (Kovalzon et al., 2006)
In proglucagon gene ( Gcg ) knockout mice, the GLP-1 receptor antagonist, exendin 9-39, led to impaired glucose tolerance when Gcg was reactivated in the pancreas, but not when intestinal Gcg was reactivated (115)
This means theres plenty of fuel in your blood, but your cells are under-fueled, leaving you fatigued
Some researchers report that microdosing at 1.0mg to 1.25mg weekly produces meaningful appetite suppression with virtually no gastrointestinal side effects