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Dosing and Administration# Liraglutide# Saxenda (obesity) : Start 0.6 mg daily, titrate weekly by 0.6 mg to 3.0 mg daily (5-week titration) Victoza (T2D) : Start 0.6 mg daily, increase to 1.2 mg, max 1.8 mg daily Subcutaneous injection, abdomen/thigh/upper arm Any time of day, with or without food No oral weight management formulation Semaglutide# Wegovy (obesity) : Start 0.25 mg weekly, titrate monthly to 2.4 mg weekly (16-week titration) Ozempic (T2D) : Start 0.25 mg weekly, titrate to 0.5 mg, max 2.0 mg weekly Rybelsus (T2D) : 3 mg daily oral for 30 days, then 7 mg, max 14 mg Oral semaglutide 25 mg (approved 2025): Oral formulation for weight management Weekly injection or daily oral tablet

Understanding these differences prevents cross-contamination of protocols

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