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That means: * We cant yet predict *who* will respond best * Optimal dosing for MCAS is still unknown * These medications are often used off-label for MCAS * Cost and access remain real barriers That said, the authors strongly emphasize something important: many MCAS patients responded to much lower doses than those typically prescribed for diabetes or obesity, which may improve tolerability and safety
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However, as GLP-1R expression is generally absent in most tumor specimens, the anticancer effects of Ex-4 may be restricted to specific patients with ovarian cancer who also have diabetes [72]
While the neuroprotective effect in preclinical studies is clear, clinical findings have so far failed to demonstrate an arresting effect on cognitive
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