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In one analysis, GHK-Cu was found to influence the expression of over 4,000 human genes, including those involved in inflammation resolution, DNA repair, antioxidant response, and ubiquitin-proteasome system regulation

This action further attenuates IMQ-induced skin inflammation in rodent models (79)

Beyond this, selection may be guided by cost and the availability of generic alternatives, although safety and efficacy should be higher priorities

The nitrogen atoms on the histidine imidazole ring and glycine amine backbone coordinate with Cu with extremely high binding affinity, forming a stable bioavailable chelate complex

Mercantepe F, Topcu A, Rakici S, Tumkaya L, Yilmaz A