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Toxic solvent residues DMF (dimethylformamide) Known liver toxin Associated with reproductive toxicity Must be removed to extremely low limits in GMP drugs DCM (dichloromethane / methylene chloride) Probable human carcinogen Central nervous system depressant Dangerous even in small amounts if injected TFA (trifluoroacetic acid) Corrosive Can remain in peptides as unmeasured TFA salt Pharmaceutical products often convert TFA salts to safer counterions Without validated HPLC, mass spectrometry, and residual solvent testing, patients may be injected with harmful chemical contaminants
Store in the original vial, sealed and protected from light and moisture until use
demonstrated that cell lines treated with foretinib and erlotinib or lapatinib [EGFR/human epidermal growth factor (HER) 2 inhibitor] synergistically inhibit HNSCC growth [100]
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