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Quebec, Ontario, British Columbia, and Alberta typically make independent coverage decisions based on cost-effectiveness analyses
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SBP reduction was mostly mediated by weight loss (7794%) in SURPASS-1, -2 and -3, while mechanisms independent from weight loss accounted for most of the tirzepatide benefit on SBP in SURPASS-4 and -5 (57 and 73%, respectively) [77]
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In addition, the authors noted that tirzepatide showed no meaningful benefit over semaglutide. Despite the widespread morbidity and mortality burden of HFpEF, current treatment options are limited, corresponding author Nils Krger, MD, with the division of pharmacoepidemiology and pharmacoeconomics at Brigham and Womens Hospital, said in a statement
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