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Liraglutide (Victoza) followed in 2010, semaglutide (Ozempic) in 2017, oral semaglutide (Rybelsus) in 2019, semaglutide for weight loss (Wegovy) in 2021, and the first GIP/GLP-1 dual agonist tirzepatide (Mounjaro) in 2022 with its weight-loss sibling Zepbound in 2023
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Dysbiosis is associated with systemic inflammation and metabolic dysfunction in diabetes, both of which can exacerbate DPN
The final model has a cross correlation efficient of 0.77 with the map
GLP-1R was found in 83% of the activated PSCs
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