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The resulting conjugate molecule activates a whopping five receptors on the cell surface and in the nucleusand in mice, it appears to offer a potent, safe treatment for obesity and diabetes ( Nature 2026, DOI: 10.1038/s41586-026-10427-5)

Diagnosis is often delayed due to gradual glandular damage and insidious symptom onset

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the STEP TEENS trial showed weight rebound after discontinuation (as in adults), suggesting that many patients may need extended or intermittent treatment

The appetite suppression that defines GLP-1 therapy means the drive to eat is something we cant count on