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Psychological distress was assessed using the Kessler Psychological Distress Scale (K6), which measures non-specific psychological distress in the past month (possible range = 024) [35, 36]

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Melanotan I is often used in clinical settings for specific conditions like erythropoietic protoporphyria

Initially, resting immune cells tend to polarize towards pro-inflammatory phenotypes, releasing pro-inflammatory and chemotactic factors to recruit assistance, often through MAPK, NF-B, and other signaling pathways

All patients in the study were identified as having either type T2DM or obesity, with the exception of one patient who had been diagnosed with prediabetes