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They were found to be equally effective at reducing depression.[ref] A study involving postmenopausal women showed that saffron tea significantly improved happiness.[ref] A randomized placebo-controlled clinical trial of 200 patients with depressive symptoms found that 3 months of 28mg of saffron supplementation daily was beneficial in reducing depression without adverse side effects

Injectable skin results: subtle glow at 23 weeks

But it does mean you're accepting risks that don't exist with topical application, for benefits that may not be meaningfully greater

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Doping control analysis of TB-500, a synthetic version of an active region of thymosin [PMID: 23084823] Laboratory literature summary: Doping control analysis of TB-500, a synthetic version of an active region of thymosin , in equine urine and plasma by liquid