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In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression

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doi.org/10.1038/nature03000 Dalmasso, G., et al

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The gut lining can take a beating during extended use of GLP-1 class medications, and some researchers believe that supporting gut integrity proactively leads to better long-term tolerance

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