Avoiding artificial sweeteners, sugar alcohols (sorbitol, xylitol), and excess caffeine also reduces osmotic diarrhea in GLP-1 users, because these substances draw additional water into the intestinal lumen
GLP-1 RAs are currently being investigated for various new areas, such as cardiovascular diseases, non-alcoholic steatohepatitis (NASH), Alzheimers disease, and chronic kidney disease
N-acetylcysteine (NAC) is the evidence-based alternative
Research peptides in this space fall into two distinct mechanistic categories: GHRH analogs (e.g., CJC-1295, Sermorelin, Tesamorelin ) bind the GHRH receptor on pituitary somatotrophs to directly stimulate GH synthesis and release GHRPs / Ghrelin mimetics (e.g., Ipamorelin, GHRP-2, GHRP-6, Hexarelin) bind the GHS-R1a receptor to amplify GH release through a separate, complementary pathway Ipamorelin falls firmly in the GHRP/ghrelin mimetic category
H., Shieh, S.-S