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This IR cascade initiates a characteristic sequence of metabolic and oxidative perturbations within mitochondria: succinate accumulation during ischemia, reverse electron transport-driven ROS generation upon reperfusion, calcium overload, opening of the mPTP, and ultimately, release of mtDAMPs

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doi: 10.1053/j.gastro.2017.01.052 22

10.3390/ijms23010305 Int

VK2735 Research# VK2735's evidence base consists of phase 2 trials: VENTURE (subcutaneous): 176 adults with obesity, 13 weeks, up to 14.7% weight loss from baseline (placebo-adjusted 13.1%) VENTURE-Oral: Oral tablet formulation, 13 weeks, up to 12.2% weight loss vs 1.3% placebo Phase 3 VANQUISH program: Planned but not yet initiated at time of writing Evidence level: Low -- promising phase 2 data only, short duration, small sample sizes, no head-to-head comparisons