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Persistent hunger despite semaglutide

GLP-1 2026213

Most GLP-1 agents require gradual dose escalation to minimize gastrointestinal side effects, meaning patients start at lower-than-maintenance titration doses and increase incrementally over 820 weeks depending on the specific medication

Weeks 5-8: Optimization and Response Assessment The second month represents an optimization phase where protocols may be adjusted based on individual response and tolerance

Status: Recruiting Double-blinded randomized clinical trial investigating the effects of subcutaneous semaglutide vs placebo on alcohol consumption in 108 patients diagnosed with alcohol use disorder and comorbid obesity over a 26-week period