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J Clin Oncol 34(Suppl), 2016
Patients perception of injectable therapy include perceived difficultly to use and fear of injections
However, emerging evidence suggests a potential link between GLP-1 therapy and altered pain perception, possibly through several mechanisms: 1- Neuroinflammation and Microglial Activation: GLP-1 receptors are expressed in the brainstem, spinal cord, and dorsal root ganglia, regions involved in pain modulation
However, there have been rare reports of thyroid tumors in animal studies of Semaglutide, so thyroid function should be monitored
and more importantly, these mechanisms remain unclear
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