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WHOOP's data found that GLP-1 users who increased their physical activity saw smaller increases in resting heart rate than less active users, suggesting regular exercise may help offset some cardiovascular effects of the therapy

Even partial freezing, where ice crystals form and then thaw, can cause irreversible damage

Rabanal-Ruiz Y, Llanos-Gonzlez E, Alcain FJ

More recently, the DAPA-CKD study (NCT03036150), studying renal outcomes with dapagliflozin in proteinuric CKD patients (25 and 75 mL/min/1.73m 2 ) with or without diabetes was stopped early due to overwhelming efficacy with dapagliflozin