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If patients are paying out of pocket, usually the dose is not that big of a factor
The use of SGLT2 inhibitors, such as Dapagliflozin and Empagliflozin at a dosage of ten milligrams per day, has proven effective in reducing the risk of kidney failure and cardiovascular death regardless of the presence of diabetes
In a statement to Insider, Novo Nordisk, the company that makes Wegovy and Ozempic, said that Gila monsters and the discovery of exendin-4 "did not have anything to do with our decision to develop long-acting GLP-1 receptor agonists" for obesity, because "that was based on GLP-1 biology in humans." But the company also said that "the GLP-1-like effect of exendin-4" in Gila monsters was "an important contribution to the field," as it led to the development of the very first injectable drug of its kind
Thats why its a good idea to talk to your doctor
Despite the potential clinical benefits of GLP-1RA plus SGLT2i combination therapy in patients with T2DM, several factors may delay this combination to become a common practice soon, such as reimbursement and costs associated with polypharmacy
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