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Advances in Migraine Pharmacotherapy: Current Landscape and Future Directions
Kerr JB, Myers M, Anderson RA
The hepatotoxic effects occur because excessive paracetamol overwhelms the liver's normal metabolic pathways, leading to accumulation of a toxic metabolite called N-acetyl-p-benzoquinone imine (NAPQI)
This gradual increase in dosage ensures a more comfortable experience for most patients
The downstream effect is more dilated vessels and improved local blood flow in injury models
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