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Glutathione (L-g-glutamyl-L-cysteinyl-glycine, GSH) is a hydrosoluble tripeptide, an important molecule containing thiol residues that are responsible for its antioxidant property ( Moreover, as a result of the winemaking process in wineries, one ton of grapes generates approximately 0.06t of lees ( In S.cerevisiae , genes involved in GSH production and regulation are well-known, as is the biological role of GSH

Both the mRNA and protein levels of Nrf2 and HO-1 were significantly elevated in the DAPA-treated si-Nrf2 mice compared with the si-Nrf2 group (Fig