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Serious drug-induced liver injury is very rare, though a few post-marketing cases have been reported where causality has not been established

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Importance of Gradual Dosage Increase The rationale behind starting with a sub-therapeutic dose during the initial weeks is to allow your body to adapt to the medication and minimize gastrointestinal side effects

Other serious risks reported include pancreatitis, gallbladder disease, worsening of diabetic retinopathy, acute kidney injury (often from dehydration due to stomach upset), low blood sugar (especially when used with insulin or a sulfonylurea), serious allergic reactions, and a risk of aspiration during anesthesia or deep sedation because Ozempic slows stomach emptying tell your care team you take it before any procedure

In rare cases, constipation may signal a need to pause or modify therapy