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Firstly, the abnormal secretion of parathyroid hormone-related peptide (PTHrP), particularly notable in squamous cancers, plays a crucial role in hypercalcemia by binding to the type I PTH/PTHrP receptor (PTHR-1) and activating pathways that promote increased calcium resorption from bones and reabsorption in the kidneys [88]
To test this hypothesis, German Holstein cows were assigned to a control group (CON, n = 26) and an L-carnitine supplemented group (CAR, n = 27, rumen-protected L-carnitine product: 125 g/cow/d, corresponded to total L-carnitine intake: 25 g/cow/d, supplied with concentrate) and received an intravenous bolus injection of lipopolysaccharides (LPS, 0.5 g/kg body weight, E
