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It is built on a 37-residue modified human amylin / pramlintide-style backbone with three rationally designed substitutions (N14E and V17R to stabilise the central alpha-helix through a salt bridge, P37Y to enhance calcitonin-receptor potency) and N-terminal acylation with a C20 eicosanedioic fatty diacid attached via a gamma-glutamic acid linker
There is ongoing research on this subject, and currently, tirzepatide is involved in a study of women with PCOS to see if it helps to regulate their menstrual cycles
Iranian Red Crescent medical journal , 16 (3), e14360
Li W, Mo J, Yang Z, Zhao Z, Mei S
JB, Lexington, KY Dr
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