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An AI-powered approach could elevate this strategy by designing a hydrogel matrix capable of achieving a zero-order, non-fluctuating release of dopamine, better mimicking natural physiological levels and potentially reducing the side effects associated with pulsed L-DOPA administration
However, this observation is somewhat difficult to reconcile with modelled data (Polle 2001)
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Neuropsychobiology 1999
[30] This metabolic pathway results in the formation of several metabolites, though the parent compound appears to be primarily responsible for the observed antiemetic effects
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