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How tirzepatide affects body composition In clinical research with adults using tirzepatide for weight management, participants generally lost substantial fat mass and also some lean mass

Some patients who consistently eat smaller meals over extended periods may experience what could be described as stomach adaptation

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This can lead to reduced muscle tone, slower recovery, and visible signs of aging

If the goal is to observe the full independent effect of Retatrutide without any confounding influence from a prior Tirzepatide cycle, a longer washout period is prudent