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Moreover, a study demonstrated greater efficacy of a first-line use of SGLT2i compared with a first-line metformin strategy in terms of life expectancy and quality-adjusted life years (38)
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High-quality studies are warranted with psychiatric outcomes as primary endpoints in order to determine whether there is a causal relationship and to identify high-risk subpopulations
The clinical implication: treating constipation with anti-nausea strategies (ginger, small meals, etc.) doesn't work because you're targeting the wrong organ
Wang Z, Saha S, Van Horn S, Thomas E, Traini C, Sathe G, et al
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