It is imperative to identify and treat diabetic cognitive impairment and develop effective targeted drugs
After decades of preclinical work, here are the ones that keep showing up: Nitric Oxide (NO) System BPC-157 interacts with the nitric oxide system, which controls blood vessel dilation, blood flow, and tissue repair signaling
Sources: [1] Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression (Dolotov et al., 2006), PubMed
Additionally, it may support weight loss by reducing oxidative stress and improving metabolic function
However, 100 mg aspirin per day taken by MD patients increased the risk of minor bleeding (e.g., epistaxis, ecchymoses, or bruising) by threefold (p = 0.001) but not the risk of major bleeding episodes (e.g., leading to hospitalization or fatality) (69)