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The effects of the leptin-GLP-1 interaction may be governed by intracellular signaling pathways, including those involving phosphorylated STAT3 and PTP1B.15,392 In Wistar rats, a diet high in fat was found to lead to a decrease in the ratio of OPG/RANKL, which resulted in increased bone resorption and ultimately a reduction in bone mass
SMD 0.21) compared with the earlier period
Barton (2014) Optimizing IGF-I for skeletal muscle therapeutics Growth Hormone & IGF Research, Volume 24, Issue 5, October 2014, Pages 157-163
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