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Diabetologia 26 : 223228 Kervran A et al

Highlights: GLP-1 users had a 37% higher hair loss risk than SGLT-2 inhibitor users, although the overall risk remained low Most cases involved temporary, non-scarring hair loss linked to rapid weight loss and nutritional changes Experts recommend maintaining good nutrition and consulting a doctor rather than stopping GLP-1 treatment Weight loss drugs called GLP-1 receptor agonists, including Ozempic, Wegovy, Mounjaro, and Zepbound, are transforming the treatment of obesity and type 2 diabetes by improving blood sugar control and promoting substantial weight loss

It was developed to mimic the action of naturally occurring MSH, a hormone involved in: Melanin production (skin pigmentation) Immune system modulation Appetite regulation Sexual arousal and libido Inflammatory balance Melanotan II works by binding to melanocortin receptors (MC1R, MC3R, MC4R, and MC5R), which are found not only in the skin but also in the brain, immune system, gut, and sexual organs

The pathophysiology of neuropathic pain varies and includes ectopic activity in damaged nerves or in adjacent nerves, dorsal root ganglion (DRG) or central pathways, and peripheral and central sensitisation involving numerous molecular mechanisms

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